The Gene Mutation That Could Cure HIV Has a Checkered Past

In the three and a half decades since HIV/AIDS was discovered, the deadly disease has killed 35 million people. While drugs now allow patients to live long lives with the virus, only one man, an American named Timothy Ray Brown, otherwise known as the “Berlin patient,” is believed to have been cured. Now, it appears he’s no longer alone.

This week, a team of British scientists from the University of Cambridge claimed to have successfully treated an HIV-positive man from London with the same stem-cell technique that Brown’s doctors used a decade ago. It involved transplanting the patient with bone marrow from a donor who had a naturally occurring mutation in a gene called CCR5. HIV uses the CCR5 protein to invade certain immune cells. Without it, the virus is locked out.

It’s the very same mutation that a Chinese researcher named He Jiankui tried to replicate last year by using the Crispr technique on at least two human babies. While the international science community condemned He’s experiment for a host of ethics violations, using Crispr and other gene-editing tools to recreate the protective effects of the CCR5 mutation might lead to treatments so widely available that we don’t have to refer to patients as the London this or the Berlin that any more. They’ll just get … treatments.


Recommended PRODUCTS
  • Chicken pox guru reveals proven method to cure chicken pox in 3 days or less.
  • Know the natural step by step plan to cure your constipation right now.
  • With 2 grocery items in my kitchen Drug companies hate this.
  • The fastest and easiest way to cure shingles in three days or less.
  • Cured Your Insomnia Using a Simple Fool-Proof Method.
  • Discover How to Cure Your Insomnia in 6 Simple Steps and Start Sleeping for 8 hours by 3 days.
  • This is a fool-proof step-by-step process guide so you can get started right away.
  • Reveals How To Cure Permanently in 3 Days or Less. 100 GUARANTEED
  • Discover The Tools To Conquer Psychological Impotence And Restore Your Sexual Confidence
  • Discover 3 Simple But Highly Effective Techniques To Start Healing.
  • 17 delicious juicing recipes to increase your testosterone
  • How to last longer in bed for men naturally.
  • This site teaches practically anyone how to change life with just a simple switch.
  • Discover how to cure nasal polyps permanently and naturally in just 4 days.
  • Learn how to cures plantar fasciitis in an easy and faster way
  • Reverse diabetes, lower blood sugar, increase weight loss in 30 days.
  • Clickbank Ads
     

    The scientists report that their “London patient” has been free and clear of the virus for 18 months. That’s still too early to call it a cure—the researchers prefer to say he’s in long-term remission—but he appears to be only the second person ever reported to have been rid of the virus using this method. The results are described in a paper published Tuesday in the journal Nature.

    While some experts are applauding the news as proof that the Berlin patient wasn’t just a fluke, others are less convinced that this particular method has much relevance for the majority of HIV/AIDS patients. Stem cell transplants are painful, risky procedures, often only proposed for the sickest of patients. The only reason they were attempted in the case of the Berlin and now the London patient is because in both cases the men also had a life-threatening cancer. It’s hard enough to find tissue-matched donors for many people, let alone locate one that also has the rare CCR5 mutation, which occurs in only 1 percent of European populations. It’s close to the boutique-iest treatment you can think of. As Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, put it to The New York Times: “It was done with Timothy Ray Brown, and now here’s another case—OK, so now what? Now where do we go with it?”

    One tantalizing possibility that is already the subject of much investment is using genetic engineering to recreate the same conditions as a transplant without as much of the risk and discomfort.

    “There’s a nice menu of things that we could possibly do now,” says Paula Cannon, a molecular microbiologist who studies HIV at the University of Southern California’s Keck School of Medicine. She says the latest data, combined with Brown’s now 10-year remission, suggests that any path to a cure for HIV/AIDS goes straight through CCR5. “What these two patients have shown us is that attacking the reservoir of infected cells while at the same time providing shiny, new HIV-resistant immune cells can result in a cure.” It’s kind of a push-and-pull strategy; one part defense, one part offense.

    Researchers and drug companies are already actively pursuing this approach, most notably California-based Sangamo, which is currently testing two HIV gene therapies in human trials. More than a decade ago, the company began using an older gene-editing tool called a zinc-finger-nuclease to knock out the CCR5 gene on a patient’s immune cells. Without it, HIV can’t infect those cells and is only be able to kill the non-engineered ones. In a way, the virus actually selects for its own demise, burning through vulnerable cells and leaving only the ones that can fight back. Scientists in the US and China have also explored similar treatments using Crispr, but so far only in mice and human cell lines. One potential advantage of Crispr is that it’s easier to make multiple edits. So in addition to knocking out CCR5, you could also supercharge those immune cells to be better able to find and destroy the virus. Some of the most promising new cancer treatments today rely on exactly that approach.

    But even if today’s report provides the most compelling evidence yet that crippling CCR5 could lead to a cure for HIV, researchers like Cannon believe it would still be inappropriate to make such an edit in a human embryo. “I’m still so angry about those Crispr babies,” says Cannon, referring to Lulu and Nana, a pair of girls who in November were reported to have been born in China with changes to their CCR5 gene intended to give them immunity to HIV. “It was a very cynical ploy to take the lowest hanging fruit for the technology and make a huge leap to editing an embryo with a completely unnecessary enhancement.”

    Crispr, for all the hype surrounding it, is better at cutting genes away than adding them in. And there just aren’t that many diseases where the fix is a piece of scarred up, dysfunctional DNA. But HIV/AIDS is an exception because a broken CCR5 gene provides such strong protection from the virus. Still, that doesn’t mean it’s ethical to edit the genome of a healthy, unborn child, with all the unknown risks that entails. That person has many ways to avoid getting HIV that don’t involve permanent alteration of their DNA. Particularly when you consider that in 15 to 20 years, a cure might well exist. And it might even arrive as a mutant form of a gene called CCR5.


    Original Article : HERE ; This post was curated & posted using : RealSpecific

     


    RELATED PRODUCTS
  • Say Goodbye To IBS With This Amazing Natural Plan That Works In Just Days.
  • Learn The Secrets To Increase The Effectiveness Of Your Immune System, Naturally.
  • Shows you a safe, natural and cheap way to cure your tonsil stones and never come back again
  • Cure CFS Naturally, Safely and Permanently With The Right Nutrients
  • How to last longer in bed for men naturally.
  • Stop Your PE and put an end to the humiliation. Make her happy
  • Simple Home Detoxification and Decompression Method Cures Permanently in 7 Days or Less.
  • With 2 grocery items in my kitchen Drug companies hate this.
  • Discover how to cure nasal polyps permanently and naturally in just 4 days.
  • It attacks the root cause of your problem - something no other 'all-natural' ED cure does.
  • Learn How To Permanently Eliminate All Types of Uterine Fibroids Within 2 Months.
  • Chicken pox guru reveals proven method to cure chicken pox in 3 days or less.
  • Yeast infections can be cured permanently in less then 90 seconds from now
  • The fastest and easiest way to cure shingles in three days or less.
  • Discover The Practical, Tested Advice To Overcome Shyness Or Social Anxiety From Your Life
  • 17 delicious juicing recipes to increase your testosterone
  • Clickbank Ads
     

    Thank you for taking the time to read our article.

    If you enjoyed our content, we'd really appreciate some "love" with a share or two.

    And ... Don't forget to have fun!

    Recommended

    VoiceRank360 Pro - [OTO4 Reseller Gold]

    Reseller get 100% commission throughout the funnel

    1-Minute WP Launcher WordPress Plugin Developer version - Discount

    Launches your new site (with all the proper settings, plugins and themes) - from one screen, with a few clicks, in 1 minute...

    Commission Sniper Basic

    The All In One Video Launch Jacking App

    Leave a Reply